Objective To explore the feasibility and clinical efficacy of ultrasonography guided placement of Freka Trelumina nasojejunal tubes. Methods From December 2017 to September 2018，52 hospitalized patients who needed Freka Trelumina nasojejunaltube were enrolled into our study from a comprehensive ICU in a tertiary hospital. The method and process of ultrasonography guided intubation were recorded，and indicators such as successful rate，length of operation，adverse reactions，compliance and clinical effects were recorded for analysis. Results Totally 50 out of 52（96.15%） patients were successfully intubated and length of operation was（26.58±8.01） min. The awaken patients had good compliance，92.3% of the patients had no cough or slight cough during intubation，and nobody experienced pharyngeal injury，aspiration，gastrointestinal perforation or any other complications. All successfully intubated patients had satisfied catheter position，gastrointestinal decompression and enteral nutrition supporting，and no tube prolapse occurred. Conclusion Ultrasonography guided intubation of Freka Trelumina nasojejunaltube isa feasible and effective new method，and can be recommended for tube establishment of early enteral nutritionsupport in critical patients.